MORPHOLOGICAL ANALYSIS OF EFFECTIVENESS OF A «BIO-GIDE» RESORBABLE MEMBRANE 

Kalmin Oleg Vital'evich, Doctor of medical sciences, professor, head of sub-department of human anatomy, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), ovkalmin@gmail.com
Nikishin Dmitriy Viktorovich, Candidate of medical sciences, associate professor, sub-department of human anatomy, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), nikishindv@gmail.com
Volodina Yuliya Mikhaylovna, Assistant, sub-department of human anatomy, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), yafonasova@mail.ru

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Background. The objective of the research is to evaluate efficiency of a «Bio-Gide» resorbable membrane for treatment of bone defects in experimental conditions.
Materials and methods. Using the histological methods the authors studied tissue samples from 9 adult rabbits from mandible artificial defect areas after 14, 28 and 42 days after surgery. In group 1 treatment was carried out using the «Bio-Gide» resorbable membrane. In the 2nd group therapy was performed with the «Bio-Gide» combined with the «Bio-Oss» osteoplastic material. In the third group the authors used the «Bio-Gide» with chitosan in combination with the «Bio-Oss».
Results. The study showed that effectiveness of the osteoregeneration is higher in samples with additional osteoplastic materials than in cases when the «Bio-Gide» was used in its pure form, as evidenced by more active vascularization and a higher relative area of bone tissue by the end of the experiment.
Conclusion. By the end of the experiment the defect area is completely closed by the immature bone tissue. Relationship between bone trabeculae corresponded to the initial stages of functional adaptation. The formed reticular and vascular tissues performed its functions. The used «Bio-Gide» underwent the process of integration into the body's own tissues and by the 42-th day was not detected in the samples. When using the «Bio-Gide» in pure form, callus is formed mainly through a cartilaginous stage. 

xenopericard, bone tissue, fibrotic tissue, regeneration, bone defect, chitosan. 

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